Dutasteride blocks both type I and type II 5-α reductase — the enzymes responsible for converting testosterone to DHT.

By lowering DHT systemically and at the follicle, Dutasteride:

• Prevents further hair miniaturization

• Stabilizes hair loss

• Protects existing density
  

It’s the most effective medication for male pattern hair loss — which is why MANE & STEEL is built around it.

Olsen EA et al.

• A randomized clinical trial of dutasteride versus finasteride in the treatment of male androgenetic alopecia.

• Journal of the American Academy of Dermatology (JAAD), 2006.

0.5 mg daily

• Common starting dose

• Suppresses both Type I and Type II 5-alpha reductase

• Produces significantly greater scalpDHT suppression than finasteride

• Effective for most men, but not maximal
  

1.0–1.5 mg daily

• Produces greater and more consistent scalp DHT suppression

• Often chosen when stabilization is incomplete at 0.5 mg

• Represents a clinical “sweet spot” for efficacy vs tolerance

• SHOWED NO PROPORTIONAL INCREASE IN ADVERSE EVENTS COMPARED TO LOWER DOSES IN TRIALS

2.0–2.5 mg daily

• Highest studied dose in human trials

• Demonstrated the greatest increase in hair count

• Produced the strongest suppression of scalp DHT

• SHOWED NO PROPORTIONAL INCREASE IN ADVERSE EVENTS COMPARED TO LOWER DOSES IN TRIALS

Core finding:

• Dutasteride showed dose-dependent suppression of scalp DHT and dose-dependent increases in hair count, with 2.5 mg outperforming all other doses, including finasteride.

• The higher the dose, the greater the improvement in hair count over time.
  

When added to Dutasteride, Minoxidil opens potassium channels at the follicle, increases blood flow, and extends the anagen (growth) phase.

This combination:

• Boosts regrowth
  

• Thickens existing hair
  

• Accelerates visible improvement
  

Think of Dutasteride as defense and Minoxidil as offense — together, they deliver maximum results.

Dutasteride has been studied for over a decade across multiple dosages and populations.

Research consistently shows:

• Significantly greater DHT reduction than Finasteride
  

• Higher rates of regrowth
  

• Stronger long-term stabilization
  

When used consistently, the Just One™ protocol is one of the most reliable methods to prevent and reverse hair loss.

Finasteride blocks only one of the two enzymes that create scalp DHT — which means DHT is still produced and continues attacking follicles.

Key clinical reasons it underperforms:

• Only reduces DHT ~70%

• Doesn’t target Type I 5-AR, which is active in the hairline

• Lower hair count improvement (~5–6% vs. 12–18% with Dutasteride)

• More “non-responders” because one DHT pathway remains active
  

Bottom line: Finasteride leaves too much DHT behind — which is why many men keep thinning on it, and why MANE & STEEL chooses Dutasteride instead.

Hair loss is a progressive condition. Once DHT shrinks a follicle past a certain threshold, it becomes permanently damaged and cannot produce a full hair again — even with medication.

Starting early means:

• Follicles are still alive

• Regrowth potential is dramatically higher

• You avoid the “transplant trap” later

• You maintain density before it’s lost

The earlier you start Just One™, the greater your long-term success.

DHT attacks the follicle slowly but relentlessly. Each hair cycle becomes:

• Shorter

• Thinner

• Weaker

• Less pigmented
  

Eventually the follicle miniaturizes so much that it goes dormant.

Dutasteride stops this process by blocking DHT at the root, allowing follicles to stabilize, recover, and re-enter the anagen (growth) phase.

This is why men who stay consistent with Just One™ see thicker, stronger, longer-lasting hair — while men who wait often lose their window for true regrowth.