Oral
Minoxidil

Dosing Overview
Physician-Guided.

How the two available strengths differ, and who each one is for.

Most Popular

2.5mg — Start Here

The established starting dose. Well-tolerated by most men. Where every Oral Minoxidil protocol begins.

Titration

5.0mg — Step Up

For men who have tolerated 2.5mg and want to step up. Physician-guided — evaluated after your first 90-day cycle.

Why Oral Often Beats
Topical — The Enzyme.

To work, minoxidil has to be converted into its active form — minoxidil sulfate — by an enzyme called sulfotransferase (SULT1A1). That conversion step is the whole story of why some men respond to minoxidil and others don't.

With topical minoxidil, that conversion has to happen right in the scalp, using whatever SULT1A1 activity exists in your own hair follicles. That activity varies a lot person to person — low follicular SULT1A1 is a well-documented reason some men see little to no results from topical minoxidil, no matter how consistently they apply it.

Oral minoxidil skips that bottleneck. It's converted to the active sulfate form primarily through first-pass metabolism in the liver — which has abundant sulfotransferase activity — before reaching the bloodstream and, ultimately, the follicle. That's a big part of why oral tends to outperform topical for men who didn't respond well to the topical route.

Topical Route

Depends On Scalp Enzyme

Activation relies on SULT1A1 activity in your own hair follicles — which varies widely between men. Low follicular activity is a documented cause of topical non-response, independent of how well you apply it.

Oral Route

Activated By The Liver

Activation happens largely through first-pass sulfonation in the liver, where SULT enzyme activity is abundant and consistent — bypassing the scalp-enzyme bottleneck that limits topical response.

How To Complete
Your Order.