Getting lean comes down to eating less than you burn. The hard part has always been appetite. We built our Body protocol around Tirzepatide for one reason: it acts on two of your gut’s appetite signals, not one. Here’s the thinking behind that decision.
After you eat, your gut releases hormones that help tell your brain you’ve had enough. Two of the big ones are GLP-1 and GIP. When your appetite runs ahead of your goal, every meal turns into a negotiation and every evening becomes a test.
The training was never the hard part. Lifting, walking, eating well: most guys can do that. The hard part is the hunger. GLP-1 medications work on those appetite signals. The question that matters is how many of them a medication acts on.
Tirzepatide and semaglutide are both once-weekly medications. The difference is what they act on.
Tirzepatide and semaglutide are the drug names. The names you hear on TV are the brand names of the FDA-approved versions.
Mounjaro, Zepbound, Ozempic and Wegovy are trademarks of their owners. MANE & STEEL’s compounded Tirzepatide is not Mounjaro or Zepbound, is not FDA-approved and is not a substitute for an FDA-approved medication.
Your gut sends more than one “I’m full” signal. Here’s how much of that picture each medication acts on.
Mechanism of action from the U.S. prescribing information for each medication. This shows what each drug acts on, not how well it works for any one person.
Your body makes its own GLP-1, but it breaks down in minutes. These medications are built to last days, which is why one shot covers the whole week.
Approximate half-life (the time for half a dose to clear) from U.S. prescribing information. Both are dosed once a week.
You don’t start high. You start low and find your sweet spot: the lowest dose that keeps your appetite in check and your progress moving, without side effects that make you feel off. If that’s where you start, that’s where you stay.
Nausea and stomach issues usually show up right after a dose goes up. Starting low gives your body time to adjust.
Appetite under control and progress steady? There’s no reason to go higher. More isn’t better. Right is better.
Your physician raises it only if you need it, based on how you feel, how you’re handling it and how your progress is trending. Never faster than every 4 weeks.
Example only, not a treatment plan. Every guy’s sweet spot is different. Your physician decides whether and when your dose changes, up to 15mg a week.
No daily pills. No complicated stack. One small injection a week, a dose set by a licensed U.S. physician, and the training basics that keep your muscle while you lean out.
Your appetite runs on two signals.
Tirzepatide works on both.
We’re not anti-anything. We looked at how these medications work and picked the one we’d want for ourselves, so that’s the one we build around.
Appetite isn’t one signal. Tirzepatide acts on both GIP and GLP-1, where semaglutide acts on GLP-1 alone.
A small injection, once a week. Pick your day and it fits around your life, your training and your schedule.
Microdose starts at 1.25mg a week; Standard Dose starts at 2.5mg. Your physician sets where you start and decides every change.
Every protocol comes with the basics: strength train, eat protein and whole foods, walk daily, sleep. The medication helps with appetite. The training is how you keep the steel.
The most common ones are stomach-related (nausea, diarrhea, constipation) and usually worse after a dose increase. That’s why we start low and climb slow.
Most companies sell every weight-loss drug under the sun. We made one call: Tirzepatide, dosed low and raised slowly by your physician, with the training basics that protect your muscle.
Same philosophy as hair: we offer the option we’d want for ourselves, with a physician guiding every step and a founder who actually answers his email.
Appetite is the hard part. Tirzepatide works on both signals. When the goal is getting lean and staying there, start with the right tool.
Your prescription is prepared for you by Strive Pharmacy, a state-licensed 503A compounding pharmacy, and shipped cold to your door with everything you need to inject.
Your exact dose and syringe units always follow your prescription label and your physician’s instructions.
Boxed warning: risk of thyroid C-cell tumors. In animal studies, Tirzepatide caused thyroid C-cell tumors; it’s unknown whether it causes them, including medullary thyroid carcinoma (MTC), in people. Do not use if you or a family member have had MTC, if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or if you’ve had a serious allergic reaction to Tirzepatide.
Possible serious side effects include pancreatitis, gallbladder problems, low blood sugar (especially with insulin or a sulfonylurea), kidney problems from dehydration and serious allergic reactions. The most common side effects are nausea, diarrhea, vomiting, constipation, stomach pain, indigestion and decreased appetite. Full safety information →
Pick Microdose or Standard Dose and check out. A licensed U.S. physician reviews your intake before anything ships. Not approved? Full refund.