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Body · The Questions Library

Who Can Get It?
What A Physician Checks.

The label criteria, what our physicians review, why BMI isn’t perfect for muscular men, and who shouldn’t take it.

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Free · 2 Minutes · Physician-reviewed
Quick AnswerThe CriteriaNot For EveryoneSources
Chris KiteBy Chris Kite, Founder of MANE & STEELLast updated October 22, 2026
Quick Answer

Do I need a BMI of 27 or 30 to get Tirzepatide?

FDA-approved Tirzepatide for weight management is labelled for adults with a BMI of 30 or more, or 27 or more with a weight-related condition such as high blood pressure, high cholesterol or sleep apnea. With MANE & STEEL, a licensed physician reviews your BMI, waist, health history, medications and goals, and compounded Tirzepatide is prescribed only when the physician decides it’s appropriate for you. People with a personal or family history of medullary thyroid cancer or MEN 2 shouldn’t take it.

The Criteria
What A Physician
Looks At.
What are the label criteria?

The approved weight-management product (Zepbound) is labelled for adults with:

  • a BMI of 30 or more, or
  • a BMI of 27 or more plus at least one weight-related condition, such as high blood pressure, high cholesterol, type 2 diabetes, obstructive sleep apnea or heart disease.

It’s meant to be used alongside a reduced-calorie diet and more physical activity.

What do your physicians review?

After checkout you complete a short medical intake. A licensed U.S. physician reviews your height, weight and BMI, your waist, your health history and family history, every medication and supplement you take, any recent labs, and your goals. They decide whether compounded Tirzepatide is appropriate for you and, if so, your starting dose. Every prescription is written for you as an individual.

Prescription required. Not approved? You get a full refund.

I lift and my BMI is high because of muscle. Does BMI still count?

BMI only uses height and weight, so it can overstate body fat in muscular men. That’s why physicians also look at waist size, health markers and history rather than BMI alone. It works both ways, though: a high BMI from muscle isn’t a reason to prescribe. The physician is looking for excess fat that’s affecting your health.

Not For Everyone
Who Shouldn’t
Take It.
Who shouldn’t take Tirzepatide?
  • Anyone with a personal or family history of medullary thyroid carcinoma (MTC), or with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Anyone who has had a serious allergic reaction to Tirzepatide or any ingredient in it.
  • Anyone already taking another GLP-1 medication, such as semaglutide.

Your physician also screens for a history of pancreatitis, gallbladder disease, kidney problems, severe stomach or bowel problems, diabetic eye disease, and medications such as insulin or a sulfonylurea that raise the risk of low blood sugar.

Can I get it anywhere in the U.S.?

Not yet. We can’t currently ship compounded Tirzepatide to Arkansas, Indiana or South Carolina. You must be 18 or older and live in a state we serve.

Safety
Read This
First.
Important Safety Information

Prescription required. A licensed physician decides whether compounded Tirzepatide is appropriate for you, and your dose.

Boxed warning: risk of thyroid C-cell tumors. In animal studies, Tirzepatide caused thyroid C-cell tumors. It is unknown whether it causes these tumors, including medullary thyroid carcinoma (MTC), in people. Do not use Tirzepatide if you or a family member have ever had MTC, or if you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Possible serious side effects include inflammation of the pancreas (pancreatitis), gallbladder problems, low blood sugar (especially with insulin or a sulfonylurea), kidney problems from dehydration and serious allergic reactions.

The most common side effects are nausea, diarrhea, vomiting, constipation, stomach pain, indigestion and decreased appetite.

Compounded medications are not FDA-approved. The FDA does not review compounded drugs for safety, effectiveness or quality. Compounded Tirzepatide is prepared by Strive Pharmacy, a state-licensed 503A compounding pharmacy. Not available in Arkansas, Indiana or South Carolina.

Next Step
Find Your
Body Protocol.

Two minutes of questions, then a short medical intake. A licensed physician decides whether compounded Tirzepatide is appropriate for you, and your dose. Not approved? Full refund.

Find Your Body Protocol
Free · 2 Minutes · Prescription required
Sources
Where This
Comes From.
  1. Zepbound (Tirzepatide) prescribing information, DailyMed
  2. SURMOUNT-1 trial record, ClinicalTrials.gov NCT04184622
  3. FDA’s concerns with unapproved GLP-1 drugs used for weight loss
  4. PubMed search: BMI misclassification of body fat in athletes
PubMed links open a search for the study named, so you can read the original. Trial and label figures describe the approved product in studies, not results from MANE & STEEL patients. Last updated October 22, 2026.
Keep Reading
The Body
Library.
All Tirzepatide Questions →Tirzepatide For Getting Lean →Tirzepatide Side Effects →Compounded vs. Brand →Tirzepatide & Hair Loss →Will I Lose Muscle? →Tirzepatide, Testosterone & TRT →Stopping Tirzepatide →Why Tirzepatide →Before You Start TRT →
References: Tirzepatide U.S. prescribing information, boxed warning and medication guide.   FDA statement on compounded GLP-1 drugs.   Full numbered sources are listed above.

Compounded medications are not FDA-approved and have not been evaluated by the FDA for safety, effectiveness or quality. Prescription required; a licensed physician decides eligibility and dose. Compounded Tirzepatide is prepared by Strive Pharmacy, a state-licensed 503A compounding pharmacy. Information about what Tirzepatide does describes the medication in general, not our compounded formulation specifically. Individual results vary. Zepbound® and Mounjaro® are registered trademarks of Eli Lilly and Company. MANE & STEEL is not affiliated with or endorsed by Eli Lilly and Company. MANE & STEEL does not claim to treat, cure or prevent any disease. This content is for educational purposes only and is not medical advice. Adults 18+ in eligible U.S. states.